Glucagon-like peptide-1 agonism - GLP-1, common in obesity medicines - is not essential to weight management, according to preclinical research led by Richard DiMarchi and Matthias Tschöp, with funding from their startup company Bluewater Biosciences.
Part of it is that we have more leisure time, and even much of our working time is sitting around. You don’t gain weight working 70 hours a week mining coal. Personally I spend a lot of my time eating, because donuts are awesome.